{"id":12428,"date":"2022-06-13T11:51:30","date_gmt":"2022-06-13T11:51:30","guid":{"rendered":"https:\/\/avellino.ai\/?page_id=12428"},"modified":"2023-01-25T23:22:00","modified_gmt":"2023-01-25T23:22:00","slug":"crispr-2","status":"publish","type":"page","link":"https:\/\/avellino.ai\/sg\/crispr-2\/","title":{"rendered":"CRISPR"},"content":{"rendered":"
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CRISPR<\/h1>\n\n\n\n

At Avellino, we are in the process of developing advanced gene therapies for corneal dystrophy using CRISPR-Cas9.<\/p>\n\n\n\n

What is CRISPR<\/h2>\n\n\n\n

CRISPR is a gene editing tool that is modeled off a naturally occurring phenomenon in bacteria. The acronym stands for \u201cClustered Regularly Interspaced Short Palindromic Repeats,\u201d which are repeated segments of DNA. Bacteria will locate one of these repeated segments of DNA in an invading virus and cut it out using an enzyme called Cas9. This disables the virus and stores the genetic information to identify the virus again in the future. Now, scientists are developing synthetic CRISPR-Cas9 to identify and remove sections of DNA that cause inherited diseases in humans.<\/p>\n\n\n\n

Gene Editing at Avellino<\/h2>\n\n\n\n

Avellino\u2019s Chief Research and Innovation Officer Dr. Tara Moore is a professor at Ulster University in Northern Ireland, where their Research Partnership Program has been working on finding a treatment for corneal diseases via CRISPR gene editing, guide RNA design, and in vitro and in vivo gene editing and treatment in animals and humans.<\/p>\n\n\n\n

To direct the focus of this research onto corneal diseases, Moore\u2019s team began using Small interfering RNA (siRNA), or \u201csilencing RNA.\u201d These siRNA are non-coding and interfere with, or silence, the expression of specific genes like those responsible for developing corneal disease. One of the Research Partnership Program\u2019s latest achievements is joint research with SiSaf Ltd. focused on the development of siRNA drug delivery technology using nano particles, and a second project focused on editing of the TGFBI gene via CRISPR-Cas 9.<\/p>\n\n\n\n

This research may lead the way toward treating select corneal dystrophies, potentially improving eyesight for millions.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

CRISPR At Avellino, we are in the process of developing advanced gene therapies for corneal dystrophy using CRISPR-Cas9. What is CRISPR CRISPR is a gene editing tool that is modeled off a naturally occurring phenomenon in bacteria. The acronym stands for \u201cClustered Regularly Interspaced Short Palindromic Repeats,\u201d which are repeated segments of DNA. Bacteria will […]<\/p>\n","protected":false},"author":16,"featured_media":0,"parent":0,"menu_order":18,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_eb_attr":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-12428","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/avellino.ai\/sg\/wp-json\/wp\/v2\/pages\/12428","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/avellino.ai\/sg\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/avellino.ai\/sg\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/avellino.ai\/sg\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/avellino.ai\/sg\/wp-json\/wp\/v2\/comments?post=12428"}],"version-history":[{"count":6,"href":"https:\/\/avellino.ai\/sg\/wp-json\/wp\/v2\/pages\/12428\/revisions"}],"predecessor-version":[{"id":13542,"href":"https:\/\/avellino.ai\/sg\/wp-json\/wp\/v2\/pages\/12428\/revisions\/13542"}],"wp:attachment":[{"href":"https:\/\/avellino.ai\/sg\/wp-json\/wp\/v2\/media?parent=12428"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}